InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLTCL1

Summary

InnateDB Gene

IDBG-1288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTCL1

Gene Name

clathrin, heavy chain-like 1

Synonyms

CHC22; CLH22; CLTCL; CLTD

Species

Homo sapiens

Ensembl Gene

ENSG00000070371

Encoded Proteins

IDBP-585090

clathrin, heavy chain-like 1

IDBP-592995

clathrin, heavy chain-like 1

IDBP-382518

clathrin, heavy chain-like 1

IDBP-589416

clathrin, heavy chain-like 1

IDBP-811645

clathrin, heavy chain-like 1

IDBP-811650

clathrin, heavy chain-like 1

IDBP-811651

clathrin, heavy chain-like 1

IDBP-811655

clathrin, heavy chain-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:19179473-19291716

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000427926	ENSP00000441158
ENST00000412649
ENST00000449918	ENSP00000443264
ENST00000458188	ENSP00000396140
ENST00000538828	ENSP00000443582
ENST00000540896
ENST00000621271	ENSP00000485020
ENST00000622493	ENSP00000479237
ENST00000617926	ENSP00000481031
ENST00000615606
ENST00000617103	ENSP00000480709
ENST00000611723

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0009653	anatomical structure morphogenesis
GO:0016192	vesicle-mediated transport
GO:0046326	positive regulation of glucose import

Cellular Component

GO:0005802	trans-Golgi network
GO:0005819	spindle
GO:0005905	coated pit
GO:0016020	membrane
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030135	coated vesicle
GO:0030136	clathrin-coated vesicle