Homo sapiens Gene: CLTCL1
Summary
InnateDB Gene IDBG-1288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLTCL1
Gene Name clathrin, heavy chain-like 1
Synonyms CHC22; CLH22; CLTCL; CLTD;
Species Homo sapiens
Ensembl Gene ENSG00000070371
Encoded Proteins
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
clathrin, heavy chain-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:19179473-19291716
Strand Reverse strand
Band q11.21
Transcripts
ENST00000427926 ENSP00000441158
ENST00000412649
ENST00000449918 ENSP00000443264
ENST00000458188 ENSP00000396140
ENST00000538828 ENSP00000443582
ENST00000540896
ENST00000621271 ENSP00000485020
ENST00000622493 ENSP00000479237
ENST00000617926 ENSP00000481031
ENST00000615606
ENST00000617103 ENSP00000480709
ENST00000611723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0009653 anatomical structure morphogenesis
GO:0016192 vesicle-mediated transport
GO:0046326 positive regulation of glucose import
Cellular Component
GO:0005802 trans-Golgi network
GO:0005819 spindle
GO:0005905 coated pit
GO:0016020 membrane
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Gap junction degradation pathway
Formation of annular gap junctions pathway
Axon guidance pathway
Gap junction trafficking pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
Endocytosis pathway
Huntington's disease pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KR87
UniProt Splice Variant
Entrez Gene 8218
UniGene
RefSeq NM_007098 NM_001835 XM_005277800 XM_005277801
HUGO HGNC:2093
OMIM 601273
CCDS CCDS46662 CCDS54497
HPRD
IMGT
EMBL AC000081 AC000085 AC000094 AC004463 L77569
GenPept
RNA Seq Atlas 8218