InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLTCL1

Summary

InnateDB Protein

IDBP-585090.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTCL1

Protein Name

clathrin, heavy chain-like 1

Synonyms

CHC22; CLH22; CLTCL; CLTD;

Species

Homo sapiens

Ensembl Protein

ENSP00000441158

InnateDB Gene

IDBG-1288 (CLTCL1)

Protein Structure

UniProt Annotation

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0009653	anatomical structure morphogenesis
GO:0016192	vesicle-mediated transport
GO:0046326	positive regulation of glucose import

Cellular Component

GO:0005802	trans-Golgi network
GO:0005819	spindle
GO:0005905	coated pit
GO:0016020	membrane
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030135	coated vesicle
GO:0030136	clathrin-coated vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001473 Clathrin, heavy chain, propeller, N-terminal
IPR015348 Clathrin, heavy chain, linker, core motif
IPR016024 Armadillo-type fold
IPR016341 Clathrin, heavy chain
IPR022365 Clathrin, heavy chain, propeller repeat

PFAM

PF00637
PF09268
PF01394

PRINTS

PIRSF

PIRSF002290

SMART

SM00299

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt