Homo sapiens Gene: CCND2
Summary
InnateDB Gene IDBG-12912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND2
Gene Name cyclin D2
Synonyms KIAK0002; MPPH3;
Species Homo sapiens
Ensembl Gene ENSG00000118971
Encoded Proteins
cyclin D2
cyclin D2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4273772-4305350
Strand Forward strand
Band p13.32
Transcripts
ENST00000261254 ENSP00000261254
ENST00000536537 ENSP00000442807
ENST00000536795
ENST00000541542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 27 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934 positive regulation of protein phosphorylation
GO:0007049 cell cycle
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
BCR pathway
REACTOME
G1 Phase pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
KEGG
Cell cycle pathway
p53 signaling pathway pathway
Wnt signaling pathway pathway
Focal adhesion pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
Il-2 receptor beta chain in t cell activation [Biocarta view]
Cyclins and cell cycle regulation [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional activation
Regulation of nuclear beta catenin signaling and target gene transcription
IL2 signaling events mediated by STAT5
Cross-References
SwissProt P30279
TrEMBL
UniProt Splice Variant
Entrez Gene 894
UniGene Hs.376071 Hs.609915 Hs.706154 Hs.706277
RefSeq NM_001759
HUGO HGNC:1583
OMIM 123833
CCDS CCDS8524
HPRD
IMGT
EMBL AF518005 AK291146 BC010958 BC089384 BT019847 CH471116 D13639 M88080 M88081 M88082 M88083 M90813 X68452
GenPept AAA51926 AAA51928 AAH10958 AAH89384 AAM54041 AAV38650 BAA02802 BAF83835 CAA48493 EAW88851
RNA Seq Atlas 894