Mus musculus Gene: Mefv
Summary
InnateDB Gene IDBG-129147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mefv
Gene Name Mediterranean fever
Synonyms FMF; pyrin; TRIM20;
Species Mus musculus
Ensembl Gene ENSMUSG00000022534
Encoded Proteins
Mediterranean fever
Mediterranean fever
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MEFV inhibits the formation of CASP8, PYCARD and NLRC4 inflammasome formation by competing with CASP8 to bind to PYCARD.
[Homo sapiens] MEFV inhibits binding of NLRP3 with PYCARD.
[Homo sapiens] PYCARD-MEFV pyroptosome is induced by PSTPIP1 in a pyrin-dependent manner.
[Homo sapiens] MEFV homodimerization is important for its ability to induce PYCARD oligomerization and CASP1 activation.
[Homo sapiens] MEFV gene is bound constitutively by CEBPB, while RELA binds to the MEFV gene upon TNFA stimulation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103313:
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3707215-3718124
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000023180 ENSMUSP00000023180
ENSMUST00000100222 ENSMUSP00000097795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
Biological Process
GO:0006954 inflammatory response
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0045087 innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
The NLRP3 inflammasome pathway
Inflammasomes pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
KEGG
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Inflammasomes pathway
The NLRP3 inflammasome pathway
KEGG
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9JJ26
TrEMBL Q32MT0
UniProt Splice Variant
Entrez Gene 54483
UniGene Mm.143718
RefSeq NM_001161790 NM_001161791 NM_019453
OMIM
CCDS CCDS27907 CCDS49745
HPRD
IMGT
MGI ID MGI:1859396
MGI Symbol Mefv
EMBL AC139347 AF143409 BC108994
GenPept AAF03766 AAI08995
RNA Seq Atlas 54483