InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mefv

Summary

InnateDB Gene

IDBG-129147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mefv

Gene Name

Mediterranean fever

Synonyms

FMF; pyrin; TRIM20

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022534

Encoded Proteins

IDBP-129149

Mediterranean fever

IDBP-129151

Mediterranean fever

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 126461680

[Homo sapiens] MEFV inhibits the formation of CASP8, PYCARD and NLRC4 inflammasome formation by competing with CASP8 to bind to PYCARD.

PMID 12615073

[Homo sapiens] MEFV inhibits binding of NLRP3 with PYCARD.

PMID 17964261

[Homo sapiens] PYCARD-MEFV pyroptosome is induced by PSTPIP1 in a pyrin-dependent manner.

PMID 17964261

[Homo sapiens] MEFV homodimerization is important for its ability to induce PYCARD oligomerization and CASP1 activation.

PMID 14514692

[Homo sapiens] MEFV gene is bound constitutively by CEBPB, while RELA binds to the MEFV gene upon TNFA stimulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103313:
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:3707215-3718124

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023180	ENSMUSP00000023180
ENSMUST00000100222	ENSMUSP00000097795

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0008270	zinc ion binding

Biological Process

GO:0006954	inflammatory response
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032695	negative regulation of interleukin-12 production
GO:0045087	innate immune response
GO:0050728	negative regulation of inflammatory response
GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production
GO:2001056	positive regulation of cysteine-type endopeptidase activity

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0030027	lamellipodium