Mus musculus Gene: Ppp1ca
Summary
InnateDB Gene IDBG-129195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1ca
Gene Name protein phosphatase 1, catalytic subunit, alpha isoform
Synonyms dism2; Ppp1c;
Species Mus musculus
Ensembl Gene ENSMUSG00000040385
Encoded Proteins
protein phosphatase 1, catalytic subunit, alpha isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PPP1CA dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PPP1CA positively regulates the TNF-alpha-induced NF-kappaB pathway at the level of IKK activation.
[Homo sapiens] PPP1CA dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172531:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4192158-4195419
Strand Forward strand
Band A
Transcripts
ENSMUST00000046094 ENSMUSP00000039109
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 271 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 271 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005981 regulation of glycogen catabolic process
GO:0006417 regulation of translation
GO:0006470 protein dephosphorylation
GO:0007143 female meiotic division
GO:0009987 cellular process
GO:0030324 lung development
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045087 innate immune response (InnateDB)
GO:0048754 branching morphogenesis of an epithelial tube
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000164 protein phosphatase type 1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0042587 glycogen granule
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0070062 extracellular vesicular exosome
GO:0070688 MLL5-L complex
GO:0072357 PTW/PP1 phosphatase complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Downregulation of TGF-beta receptor signaling pathway
Disease pathway
Signaling by GPCR pathway
Loss of Function of SMAD4 in Cancer pathway
DARPP-32 events pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
TGF-beta receptor signaling activates SMADs pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of TGFBR2 in Cancer pathway
Lipid digestion, mobilization, and transport pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Opioid Signalling pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mRNA surveillance pathway pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Focal adhesion pathway
Long-term potentiation pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
Wnt pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by GPCR pathway
Opioid Signalling pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
DARPP-32 events pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
mRNA surveillance pathway pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Focal adhesion pathway
Long-term potentiation pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Protein kinase a at the centrosome [Biocarta view]
PID NCI
BMP receptor signaling
ALK1 signaling events
TGF-beta receptor signaling
Cross-References
SwissProt P62137
TrEMBL
UniProt Splice Variant
Entrez Gene 19045
UniGene Mm.474260
RefSeq NM_031868
OMIM
CCDS CCDS29421
HPRD
IMGT
MGI ID MGI:103016
MGI Symbol Ppp1ca
EMBL AK007932 AK028392 AK090070 AK151582 AK152667 AK153517 AK159575 AK167244 AK167538 AK167880 AK167981 BC014828 U25809
GenPept AAC99814 AAH14828 BAB25358 BAC25928 BAC41078 BAE30522 BAE31402 BAE32060 BAE35196 BAE39365 BAE39605 BAE39893 BAE39973
RNA Seq Atlas 19045