InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hrh4

Summary

InnateDB Gene

IDBG-129289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hrh4

Gene Name

histamine receptor H4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037346

Encoded Proteins

IDBP-129291

histamine receptor H4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21469095

Hrh4 is a histamine receptor that can mediate cytokine production (e.g. Il6) from mast cells. Hrh4 is also able to synergize with other inflammatory signals, such as LPS, to potentiate cytokine production and contribute to inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 21469095

[Homo sapiens] HRH4 is a histamine receptor that can mediate cytokine production (e.g. IL6) from mast cells. HRH4 is also able to synergize with other inflammatory signals, such as LPS, to potentiate cytokine production and contribute to inflammation. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134489:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:13006990-13022882

Strand

Forward strand

Band

Transcripts

ENSMUST00000041676

ENSMUSP00000041061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0043408	regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)