InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hrh4

Summary

InnateDB Protein

IDBP-129291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hrh4

Protein Name

histamine receptor H4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041061

InnateDB Gene

IDBG-129289 (Hrh4)

Protein Structure

UniProt Annotation

Function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0043408	regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2429635

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR008102 Histamine H4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01726

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91ZY2