InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ing3

Summary

InnateDB Gene

IDBG-129480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ing3

Gene Name

inhibitor of growth family, member 3

Synonyms

1300013A07Rik; P47ING3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029670

Encoded Proteins

IDBP-129482

inhibitor of growth family, member 3

IDBP-249752

inhibitor of growth family, member 3

IDBP-789649

inhibitor of growth family, member 3

IDBP-540192

inhibitor of growth family, member 3

IDBP-789652

inhibitor of growth family, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071243:
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:21949571-21976038

Strand

Forward strand

Band

A3.1

Transcripts

ENSMUST00000031680	ENSMUSP00000031680
ENSMUST00000115389	ENSMUSP00000111047
ENSMUST00000144534
ENSMUST00000136200	ENSMUSP00000138656
ENSMUST00000151473	ENSMUSP00000120651
ENSMUST00000152877	ENSMUSP00000138244
ENSMUST00000146684
ENSMUST00000149728
ENSMUST00000136161
ENSMUST00000141689

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071243

View Gene Order

ENSBTAG00000016332

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.39999 Mm.475439 Mm.475555

RefSeq

NM_023626 XM_006505166 XM_006505167

OMIM

CCDS

CCDS39434

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas