InnateDB Protein
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IDBP-129482.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ing3
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Protein Name
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inhibitor of growth family, member 3
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Synonyms
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1300013A07Rik; P47ING3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031680
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InnateDB Gene
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IDBG-129480 (Ing3)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919027
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VEK6
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PhosphoSite |
PhosphoSite-Q8VEK6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
71777
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UniGene |
Mm.475555
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RefSeq |
NP_076115
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MGI ID |
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MGI Symbol |
Ing3
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OMIM |
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CCDS |
CCDS39434
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HPRD |
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IMGT |
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EMBL |
AK080787
AY007791
BC005721
BC018342
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GenPept |
AAG23286
AAH05721
AAH18342
BAC38021
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