Mus musculus Gene: Rock2
Summary
InnateDB Gene IDBG-129486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rock2
Gene Name Rho-associated coiled-coil containing protein kinase 2
Synonyms B230113H15Rik; mKIAA0619; Rho-kinase; Rock-II; Rock2m; ROKalpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000020580
Encoded Proteins
Rho-associated coiled-coil containing protein kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134318:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:16894978-16988274
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000020904 ENSMUSP00000020904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001843 neural tube closure
GO:0006468 protein phosphorylation
GO:0007266 Rho protein signal transduction
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825 positive regulation of centrosome duplication
GO:0016525 negative regulation of angiogenesis
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0045616 regulation of keratinocyte differentiation
GO:0051298 centrosome duplication
Cellular Component
GO:0005813 centrosome
GO:0031616 spindle pole centrosome
GO:0036464 cytoplasmic ribonucleoprotein granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Axon guidance pathway
Signal Transduction pathway
GPCR downstream signaling pathway
EPHA-mediated growth cone collapse pathway
VEGFA-VEGFR2 Pathway pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
Ccr3 signaling in eosinophils [Biocarta view]
PID NCI
Signaling events mediated by focal adhesion kinase
Plasma membrane estrogen receptor signaling
PLK1 signaling events
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL F8VPK5 Q3TR46 Q3UMT5 Q6A035 Q8CC95
UniProt Splice Variant
Entrez Gene 19878
UniGene Mm.276024 Mm.415751 Mm.417354
RefSeq NM_009072 XM_006515019 XM_006515020 XM_006515021
OMIM
CCDS CCDS36410
HPRD
IMGT
MGI ID MGI:107926
MGI Symbol Rock2
EMBL AC155305 AK033588 AK144687 AK163082 AK172983
GenPept BAC28376 BAD32261 BAE26013 BAE37184
RNA Seq Atlas 19878