InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rock2

Summary

InnateDB Gene

IDBG-129486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rock2

Gene Name

Rho-associated coiled-coil containing protein kinase 2

Synonyms

B230113H15Rik; mKIAA0619; Rho-kinase; Rock-II; Rock2m; ROKalpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020580

Encoded Proteins

IDBP-129488

Rho-associated coiled-coil containing protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134318:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:16894978-16988274

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000020904

ENSMUSP00000020904

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001843	neural tube closure
GO:0006468	protein phosphorylation
GO:0007266	Rho protein signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825	positive regulation of centrosome duplication
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0045616	regulation of keratinocyte differentiation
GO:0051298	centrosome duplication