InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rock2

Summary

InnateDB Protein

IDBP-129488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rock2

Protein Name

Rho-associated coiled-coil containing protein kinase 2

Synonyms

B230113H15Rik; mKIAA0619; Rho-kinase; Rock-II; Rock2m; ROKalpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020904

InnateDB Gene

IDBG-129486 (Rock2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001843	neural tube closure
GO:0006468	protein phosphorylation
GO:0007266	Rho protein signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825	positive regulation of centrosome duplication
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0045616	regulation of keratinocyte differentiation
GO:0051298	centrosome duplication

Cellular Component

GO:0005813	centrosome
GO:0031616	spindle pole centrosome
GO:0036464	cytoplasmic ribonucleoprotein granule

Protein Structure and Domains

PDB ID

MGI:107926

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010978 tRNA-binding arm
IPR011009 Protein kinase-like domain
IPR015008 Rho binding domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020684 Rho-associated protein kinase

PFAM

PF00069
PF07714
PF00169
PF00130
PF08912
PF00433

PRINTS

PR00109

PIRSF

PIRSF037568

SMART

SM00133
SM00233
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References