Mus musculus Gene: Otud5
Summary
InnateDB Gene IDBG-129612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otud5
Gene Name OTU domain containing 5
Synonyms AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7
Species Mus musculus
Ensembl Gene ENSMUSG00000031154
Encoded Proteins
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] OTUD5 is a deubiquitinase that regulates Type I interferon (IFN) production where OTUD5 selectively cleaves the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signalling complex containing TBK1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068308:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7841364-7876626
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033494 ENSMUSP00000033494
ENSMUST00000115668 ENSMUSP00000111332
ENSMUST00000115667 ENSMUSP00000111331
ENSMUST00000115666 ENSMUSP00000111330
ENSMUST00000115665 ENSMUSP00000111329
ENSMUST00000152899
ENSMUST00000150644
ENSMUST00000130908
ENSMUST00000148841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0032496 response to lipopolysaccharide
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Innate Immune System pathway
Immune System pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.416357
RefSeq NM_001290536 NM_001290537 NM_138604 XM_006527663 XM_006527664 XM_006527665 XM_006527667 XM_006527668
OMIM
CCDS CCDS29975 CCDS72335 CCDS72336
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas