Mus musculus Gene: Otud5
Summary
InnateDB Gene IDBG-129612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otud5
Gene Name OTU domain containing 5
Synonyms AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7;
Species Mus musculus
Ensembl Gene ENSMUSG00000031154
Encoded Proteins
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] OTUD5 is a deubiquitinase that regulates Type I interferon (IFN) production where OTUD5 selectively cleaves the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signalling complex containing TBK1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068308:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7841364-7876626
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033494 ENSMUSP00000033494
ENSMUST00000115668 ENSMUSP00000111332
ENSMUST00000115667 ENSMUSP00000111331
ENSMUST00000115666 ENSMUSP00000111330
ENSMUST00000115665 ENSMUSP00000111329
ENSMUST00000152899
ENSMUST00000150644
ENSMUST00000130908
ENSMUST00000148841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0032496 response to lipopolysaccharide
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Innate Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q3U2S4
TrEMBL
UniProt Splice Variant
Entrez Gene 54644
UniGene Mm.416357
RefSeq NM_138604 XM_006527664 XM_006527665 NM_001290536 NM_001290537 XM_006527663 XM_006527667 XM_006527668
OMIM
CCDS CCDS29975 CCDS72335 CCDS72336
HPRD
IMGT
MGI ID MGI:1859615
MGI Symbol Otud5
EMBL AF229642 AK009620 AK149777 AK155131 AK171874 AL671978 AL671995 BC016529 BC051111
GenPept AAF66952 AAH16529 AAH51111 BAB26396 BAE29078 BAE33066 BAE42712 CAM13606 CAM24561
RNA Seq Atlas 54644