Version 5.4
| Mus musculus Gene: Otud5 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-129612.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Otud5 | ||||||||
| Gene Name | OTU domain containing 5 | ||||||||
| Synonyms | AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000031154 | ||||||||
| Encoded Proteins |
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
OTU domain containing 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] OTUD5 is a deubiquitinase that regulates Type I interferon (IFN) production where OTUD5 selectively cleaves the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signalling complex containing TBK1.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068308:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome X:7841364-7876626 | ||||||||
| Strand | Forward strand | ||||||||
| Band | A1.1 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||
| PID BIOCARTA | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Innate Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
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| KEGG |
RIG-I-like receptor signaling pathway pathway
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| INOH | |||||||||
| PID BIOCARTA | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q3U2S4 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 54644 | ||||||||
| UniGene | Mm.416357 | ||||||||
| RefSeq | NM_138604 XM_006527664 XM_006527665 NM_001290536 NM_001290537 XM_006527663 XM_006527667 XM_006527668 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS29975 CCDS72335 CCDS72336 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1859615 | ||||||||
| MGI Symbol | Otud5 | ||||||||
| EMBL | AF229642 AK009620 AK149777 AK155131 AK171874 AL671978 AL671995 BC016529 BC051111 | ||||||||
| GenPept | AAF66952 AAH16529 AAH51111 BAB26396 BAE29078 BAE33066 BAE42712 CAM13606 CAM24561 | ||||||||
| RNA Seq Atlas | 54644 | ||||||||