InnateDB Protein
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IDBP-249126.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Otud5
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Protein Name
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OTU domain containing 5
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Synonyms
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AA407879; AI553596; BB114028; DUBA; DXImx46e; Sfc7;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111332
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InnateDB Gene
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IDBG-129612 (Otud5)
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Protein Structure
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Function |
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro) (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004843
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ubiquitin-specific protease activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1859615
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InterPro |
IPR003323
Ovarian tumour, otubain
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PFAM |
PF02338
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U2S4
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PhosphoSite |
PhosphoSite-Q3U2S4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54644
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UniGene |
Mm.416357
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RefSeq |
NP_001277466
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MGI ID |
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MGI Symbol |
Otud5
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OMIM |
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CCDS |
CCDS72335
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HPRD |
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IMGT |
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EMBL |
AF229642
AK009620
AK149777
AK155131
AK171874
AL671978
AL671995
BC016529
BC051111
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GenPept |
AAF66952
AAH16529
AAH51111
BAB26396
BAE29078
BAE33066
BAE42712
CAM13606
CAM24561
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