Version 5.4
Mus musculus Gene: Pim2
Summary
InnateDB Gene IDBG-129634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pim2
Gene Name proviral integration site 2
Synonyms DXCch3; Pim-2
Species Mus musculus
Ensembl Gene ENSMUSG00000031155
Encoded Proteins
IDBP-129636
proviral integration site 2
IDBP-788788
proviral integration site 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102096:
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7878262-7883432
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033495 ENSMUSP00000033495
ENSMUST00000126715
ENSMUST00000145177
ENSMUST00000190448 ENSMUSP00000140602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0008637 apoptotic mitochondrial changes
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009615 response to virus
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102096
View Gene Order
ENSBTAG00000004597
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05221
Acute myeloid leukemia pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05221
Acute myeloid leukemia pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.347478
RefSeq NM_138606
OMIM
CCDS CCDS29976
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca