Version 5.4
Homo sapiens Gene: PIM2
Summary
InnateDB Gene IDBG-64771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIM2
Gene Name pim-2 oncogene
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102096
Encoded Proteins
IDBP-64773
pim-2 oncogene
IDBP-370979
pim-2 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48913182-48919024
Strand Reverse strand
Band p11.23
Transcripts
ENST00000376509 ENSP00000365692
ENST00000442430 ENSP00000410960
ENST00000485431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007140 male meiosis
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008637 apoptotic mitochondrial changes
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009615 response to virus
GO:0010508 positive regulation of autophagy
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050821 protein stabilization
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031155
View Gene Order
ENSBTAG00000004597
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05221
Acute myeloid leukemia pathway
INOH
PID NCI
Cross-References
SwissProt Q9P1W9
TrEMBL A0A024QYW7 C9J8V9
UniProt Splice Variant
Entrez Gene 11040
UniGene Hs.727148
RefSeq NM_006875
HUGO HGNC:8987
OMIM 300295
CCDS CCDS14312
HPRD
IMGT
EMBL AB042425 AF207550 AK290931 BC018111 CH471224 U77735
GenPept AAC78506 AAH18111 BAA95613 BAF83620 EAW50729 EAW50730
RNA Seq Atlas 11040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca