InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tfap4

Summary

InnateDB Gene

IDBG-129693.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfap4

Gene Name

transcription factor AP4

Synonyms

AI642933; AP-4; bHLHc41; D930048N17Rik; Tcfap4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005718

Encoded Proteins

IDBP-129695

transcription factor AP4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090447:
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:4544661-4559720

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005862

ENSMUSP00000005862

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043922	negative regulation by host of viral transcription
GO:0043923	positive regulation by host of viral transcription
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071157	negative regulation of cell cycle arrest
GO:0071549	cellular response to dexamethasone stimulus
GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000090447

View Gene Order

ENSBTAG00000033174

Not yet available

Cross-References

SwissProt

TrEMBL

Q8BWA4 Q9JIZ5

UniProt Splice Variant

Entrez Gene

83383

UniGene

Mm.273210 Mm.406682

RefSeq

NM_031182 XM_006522764 XM_006522766

OMIM

CCDS

CCDS27919

HPRD

IMGT

MGI ID

MGI:103239

MGI Symbol

Tfap4

EMBL

AC157597 AF161262 AK053091 AK166424 BC047270 BC054777 CH466521

GenPept

AAF80448 AAH47270 AAH54777 BAC35263 BAE38767 EDK97233

RNA Seq Atlas

83383