Version 5.4
Homo sapiens Gene: TFAP4
Summary
InnateDB Gene IDBG-12589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFAP4
Gene Name transcription factor AP-4 (activating enhancer binding protein 4)
Synonyms AP-4; bHLHc41
Species Homo sapiens
Ensembl Gene ENSG00000090447
Encoded Proteins
IDBP-12591
transcription factor AP-4 (activating enhancer binding protein 4)
IDBP-749831
IDBP-753339
IDBP-749111
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4257186-4273075
Strand Reverse strand
Band p13.3
Transcripts
ENST00000204517 ENSP00000204517
ENST00000575672
ENST00000572393 ENSP00000459390
ENST00000575300
ENST00000575320
ENST00000573476 ENSP00000460067
ENST00000574639 ENSP00000461352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
Experimentally validated
Total 86 [view]
Protein-Protein 84 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008285 negative regulation of cell proliferation
GO:0010629 negative regulation of gene expression
GO:0043065 positive regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071157 negative regulation of cell cycle arrest
GO:0071549 cellular response to dexamethasone stimulus
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005718
View Gene Order
ENSBTAG00000033174
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513305
RefSeq NM_003223
HUGO
OMIM
CCDS CCDS10510
HPRD 11795
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca