Homo sapiens Gene: RAB27A
Summary
InnateDB Gene IDBG-12971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB27A
Gene Name RAB27A, member RAS oncogene family
Synonyms GS2; HsT18676; RAB27; RAM;
Species Homo sapiens
Ensembl Gene ENSG00000069974
Encoded Proteins
RAB27A, member RAS oncogene family
RAB27A, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:55202966-55319113
Strand Reverse strand
Band q21.3
Transcripts
ENST00000336787 ENSP00000337761
ENST00000396307 ENSP00000379601
ENST00000569493 ENSP00000456059
ENST00000563262 ENSP00000457595
ENST00000568803 ENSP00000457517
ENST00000565972 ENSP00000456536
ENST00000566877 ENSP00000454695
ENST00000564609 ENSP00000455012
ENST00000567380 ENSP00000458127
ENST00000567639
ENST00000565776
ENST00000561545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0031489 myosin V binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006605 protein targeting
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019882 antigen processing and presentation
GO:0030318 melanocyte differentiation
GO:0032400 melanosome localization
GO:0032402 melanosome transport
GO:0043316 cytotoxic T cell degranulation
GO:0043320 natural killer cell degranulation
GO:0043473 pigmentation
GO:0044267 cellular protein metabolic process
GO:0045921 positive regulation of exocytosis
GO:0051875 pigment granule localization
GO:0051904 pigment granule transport
GO:0071985 multivesicular body sorting pathway
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030141 secretory granule
GO:0030425 dendrite
GO:0030667 secretory granule membrane
GO:0032585 multivesicular body membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0070382 exocytic vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Insulin processing pathway
Peptide hormone metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654978
RefSeq NM_004580 NM_183234 NM_183235 NM_183236 XM_005254576 XM_005254577
HUGO
OMIM
CCDS CCDS10153
HPRD 04845
IMGT
EMBL
GenPept
RNA Seq Atlas