Homo sapiens Gene: AZU1
Summary
InnateDB Gene IDBG-13012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AZU1
Gene Name azurocidin 1
Synonyms AZAMP; AZU; CAP37; HBP; HUMAZUR; NAZC;
Species Homo sapiens
Ensembl Gene ENSG00000172232
Encoded Proteins
azurocidin 1
azurocidin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:825097-832018
Strand Forward strand
Band p13.3
Transcripts
ENST00000233997 ENSP00000233997
ENST00000592205 ENSP00000481172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008201 heparin binding
GO:0015643 toxic substance binding
Biological Process
GO:0001774 microglial cell activation
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008347 glial cell migration
GO:0042117 monocyte activation
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0045123 cellular extravasation
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045785 positive regulation of cell adhesion
GO:0048246 macrophage chemotaxis
GO:0050725 positive regulation of interleukin-1 beta biosynthetic process
GO:0050754 positive regulation of fractalkine biosynthetic process
GO:0050766 positive regulation of phagocytosis
GO:0050829 defense response to Gram-negative bacterium
GO:0050930 induction of positive chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0042582 azurophil granule
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P20160
TrEMBL
UniProt Splice Variant
Entrez Gene 566
UniGene Hs.72885
RefSeq NM_001700
HUGO HGNC:913
OMIM 162815
CCDS CCDS12044
HPRD 01221
IMGT
EMBL AC004799 BC069495 BC093931 BC093933 M96326 X58794
GenPept AAB59353 AAH69495 AAH93931 AAH93933 CAA41601
RNA Seq Atlas 566