InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AZU1

Summary

InnateDB Gene

IDBG-13012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AZU1

Gene Name

azurocidin 1

Synonyms

AZAMP; AZU; CAP37; HBP; HUMAZUR; NAZC

Species

Homo sapiens

Ensembl Gene

ENSG00000172232

Encoded Proteins

IDBP-13016

azurocidin 1

IDBP-812713

azurocidin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:825097-832018

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000233997	ENSP00000233997
ENST00000592205	ENSP00000481172

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008201	heparin binding
GO:0015643	toxic substance binding

Biological Process

GO:0001774	microglial cell activation
GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008347	glial cell migration
GO:0042117	monocyte activation
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043114	regulation of vascular permeability
GO:0045123	cellular extravasation
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045785	positive regulation of cell adhesion
GO:0048246	macrophage chemotaxis
GO:0050725	positive regulation of interleukin-1 beta biosynthetic process
GO:0050754	positive regulation of fractalkine biosynthetic process
GO:0050766	positive regulation of phagocytosis
GO:0050829	defense response to Gram-negative bacterium
GO:0050930	induction of positive chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0042582	azurophil granule
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

P20160

TrEMBL

UniProt Splice Variant

Entrez Gene

566

UniGene

Hs.72885

RefSeq

NM_001700

HUGO

HGNC:913

OMIM

162815

CCDS

CCDS12044

HPRD

IMGT

EMBL

AC004799 BC069495 BC093931 BC093933 M96326 X58794

GenPept

AAB59353 AAH69495 AAH93931 AAH93933 CAA41601

RNA Seq Atlas

566