Version 5.4
Mus musculus Gene: Fcer2a
Summary
InnateDB Gene IDBG-130417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcer2a
Gene Name Fc receptor, IgE, low affinity II, alpha polypeptide
Synonyms CD23; Fce2; Fcer2; Ly-42
Species Mus musculus
Ensembl Gene ENSMUSG00000005540
Encoded Proteins
IDBP-130419
Fc receptor, IgE, low affinity II, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104921:
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:3681737-3694174
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000005678 ENSMUSP00000005678
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 0
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104921
View Gene Order
ENSBTAG00000004270
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04640
Hematopoietic cell lineage pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_299
Signaling by NOTCH pathway
REACT_163910
NOTCH2 intracellular domain regulates transcription pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P20693
TrEMBL
UniProt Splice Variant
Entrez Gene 14128
UniGene Mm.1233
RefSeq NM_001253737 NM_001253739 NM_001253743 NM_001253747 NM_013517 XM_006508697
OMIM
CCDS CCDS22071
HPRD
IMGT
MGI ID MGI:95497
MGI Symbol Fcer2a
EMBL M34163 M99371 X64223 X64224
GenPept AAA37603 AAA74898 CAA45532 CAA45533
RNA Seq Atlas 14128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca