InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcer2a

Summary

InnateDB Protein

IDBP-130419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcer2a

Protein Name

Fc receptor, IgE, low affinity II, alpha polypeptide

Synonyms

CD23; Fce2; Fcer2; Ly-42;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005678

InnateDB Gene

IDBG-130417 (Fcer2a)

Protein Structure

UniProt Annotation

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	0
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

Biological Process

GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051712	positive regulation of killing of cells of other organism
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process