Version 5.4
Homo sapiens Gene: VPS41
Summary
InnateDB Gene IDBG-13045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS41
Gene Name vacuolar protein sorting 41 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006715
Encoded Proteins
IDBP-13047
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-13049
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-238436
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372740
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372741
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372743
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372745
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372748
vacuolar protein sorting 41 homolog (S. cerevisiae)
IDBP-372752
vacuolar protein sorting 41 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:38722963-38932394
Strand Reverse strand
Band p14.1
Transcripts
ENST00000310301 ENSP00000309457
ENST00000265745 ENSP00000265745
ENST00000395969 ENSP00000379297
ENST00000448833 ENSP00000391980
ENST00000439468 ENSP00000395410
ENST00000413141 ENSP00000412974
ENST00000414632 ENSP00000411919
ENST00000418457 ENSP00000407835
ENST00000457055 ENSP00000398584
ENST00000490924
ENST00000482217
ENST00000462429
ENST00000466017
ENST00000485955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008150 biological_process
GO:0016192 vesicle-mediated transport
GO:0048193 Golgi vesicle transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005798 Golgi-associated vesicle
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030897 HOPS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041236
View Gene Order
ENSBTAG00000007305
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148721 Hs.605850 Hs.638126
RefSeq NM_014396 NM_080631
HUGO
OMIM
CCDS CCDS5457 CCDS5458
HPRD 10402
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca