Version 5.4
Mus musculus Gene: Ywhaq
Summary
InnateDB Gene IDBG-130670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ywhaq
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Synonyms 2700028P07Rik; AA409740; AU021156; R74690
Species Mus musculus
Ensembl Gene ENSMUSG00000076432
Encoded Proteins
IDBP-130672
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
IDBP-259105
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
IDBP-534296
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
IDBP-541364
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134308:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5\' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21390071-21417637
Strand Reverse strand
Band A1.3
Transcripts
ENSMUST00000103002 ENSMUSP00000100067
ENSMUST00000049531 ENSMUSP00000106602
ENSMUST00000135088 ENSMUSP00000123605
ENSMUST00000155480 ENSMUSP00000117118
ENSMUST00000140710
ENSMUST00000146206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 260 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 260 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0047485 protein N-terminus binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0021762 substantia nigra development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134308
View Gene Order
ENSBTAG00000002108
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_209837
Membrane Trafficking pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04110
Cell cycle pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_25
FSH pathway
REACTOME
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_578
Apoptosis pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_11123
Membrane Trafficking pathway
REACT_219199
Activation of BH3-only proteins pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_222195
Intrinsic Pathway for Apoptosis pathway
REACT_219580
Activation of BAD and translocation to mitochondria pathway
REACT_219454
Apoptosis pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04110
Cell cycle pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
Fas signaling pathway pathway
PID NCI
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL A3KML3 F6VW30
UniProt Splice Variant
Entrez Gene 22630
UniGene Mm.382828 Mm.408354 Mm.470691
RefSeq XM_006516819 XM_006538407 XM_006543856 NM_011739
OMIM
CCDS CCDS25837
HPRD
IMGT
MGI ID MGI:891963
MGI Symbol Ywhaq
EMBL AC140457 AK145568 AK146371 AK150850 AK151437 AK151715 AK151864 AK159403 AK159817 AK163237 AK167397 AL929409 BC080802 BC085299 BC090838 BC106164 BC132252 BC132530 CH466527 CH466663 D87662 U56243 U57312
GenPept AAB72023 AAC53257 AAH80802 AAH85299 AAH90838 AAI06165 AAI32253 AAI32531 BAA13423 BAE26517 BAE27120 BAE29907 BAE30400 BAE30634 BAE30752 BAE35055 BAE35397 BAE37249 BAE39486 CAI25590 EDL31070 EDL34014
RNA Seq Atlas 100039786 102634437 22630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca