Mus musculus Gene: Ywhaq
Summary
InnateDB Gene IDBG-130670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ywhaq
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Synonyms 2700028P07Rik; AA409740; AU021156; R74690;
Species Mus musculus
Ensembl Gene ENSMUSG00000076432
Encoded Proteins
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134308:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5\' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21390071-21417637
Strand Reverse strand
Band A1.3
Transcripts
ENSMUST00000103002 ENSMUSP00000100067
ENSMUST00000049531 ENSMUSP00000106602
ENSMUST00000135088 ENSMUSP00000123605
ENSMUST00000155480 ENSMUSP00000117118
ENSMUST00000140710
ENSMUST00000146206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 260 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 260 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0047485 protein N-terminus binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0021762 substantia nigra development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptosis pathway
Membrane Trafficking pathway
Activation of BAD and translocation to mitochondria pathway
Activation of BH3-only proteins pathway
Translocation of GLUT4 to the plasma membrane pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Neurotrophin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
TNFalpha pathway
TCR pathway
IL3 pathway
FSH pathway
REACTOME
Apoptosis pathway
Activation of BH3-only proteins pathway
Translocation of GLUT4 to the plasma membrane pathway
Intrinsic Pathway for Apoptosis pathway
Activation of BAD and translocation to mitochondria pathway
Membrane Trafficking pathway
Activation of BH3-only proteins pathway
Translocation of GLUT4 to the plasma membrane pathway
Intrinsic Pathway for Apoptosis pathway
Activation of BAD and translocation to mitochondria pathway
Apoptosis pathway
Membrane Trafficking pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Pathogenic Escherichia coli infection pathway
INOH
Fas signaling pathway pathway
IL-7 signaling pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.382828 Mm.408354 Mm.470691
RefSeq NM_011739 XM_006516819 XM_006538407 XM_006543856
OMIM
CCDS CCDS25837
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas