Version 5.4
Mus musculus Gene: Klc2
Summary
InnateDB Gene IDBG-130893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klc2
Gene Name kinesin light chain 2
Synonyms 8030455F02Rik; AW212649; KLC 2; KLC-2
Species Mus musculus
Ensembl Gene ENSMUSG00000024862
Encoded Proteins
IDBP-130895
kinesin light chain 2
IDBP-253260
kinesin light chain 2
IDBP-253262
kinesin light chain 2
IDBP-273812
kinesin light chain 2
IDBP-531990
kinesin light chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174996:
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5107746-5118560
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025798 ENSMUSP00000025798
ENSMUST00000113728 ENSMUSP00000109357
ENSMUST00000113727 ENSMUSP00000109356
ENSMUST00000116563 ENSMUSP00000112262
ENSMUST00000142255
ENSMUST00000137403
ENSMUST00000149806
ENSMUST00000135827
ENSMUST00000156717 ENSMUSP00000122458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
Biological Process
GO:0008088 axon cargo transport
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005871 kinesin complex
GO:0016020 membrane
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174996
View Gene Order
ENSBTAG00000019334
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271648
RefSeq NM_008451 XM_006531667
OMIM
CCDS CCDS37889
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca