Version 5.4
Homo sapiens Gene: KLC2
Summary
InnateDB Gene IDBG-58526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLC2
Gene Name kinesin light chain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174996
Encoded Proteins
IDBP-58528
kinesin light chain 2
IDBP-242341
kinesin light chain 2
IDBP-242343
kinesin light chain 2
IDBP-242345
kinesin light chain 2
IDBP-242347
kinesin light chain 2
IDBP-378934
kinesin light chain 2
IDBP-378936
kinesin light chain 2
IDBP-378941
kinesin light chain 2
IDBP-592878
kinesin light chain 2
IDBP-600289
kinesin light chain 2
IDBP-593439
kinesin light chain 2
IDBP-594212
kinesin light chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66257294-66267860
Strand Forward strand
Band q13.2
Transcripts
ENST00000316924 ENSP00000314837
ENST00000394078 ENSP00000377641
ENST00000394067 ENSP00000377631
ENST00000394066 ENSP00000377630
ENST00000394065 ENSP00000377629
ENST00000417856 ENSP00000399403
ENST00000440228 ENSP00000396952
ENST00000421552 ENSP00000408484
ENST00000461611 ENSP00000434538
ENST00000475757 ENSP00000431253
ENST00000483152
ENST00000531240 ENSP00000436577
ENST00000526758 ENSP00000437026
ENST00000534023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0019894 kinesin binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007596 blood coagulation
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0016938 kinesin I complex
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024862
View Gene Order
ENSBTAG00000019334
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.280792 Hs.568939 Hs.629588
RefSeq NM_001134774 NM_001134775 NM_001134776 NM_022822 XM_005274182 XM_005274183
HUGO
OMIM
CCDS CCDS44653 CCDS8130
HPRD 13917
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca