Homo sapiens Gene: KLC2
Summary
InnateDB Gene IDBG-58526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLC2
Gene Name kinesin light chain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174996
Encoded Proteins
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
kinesin light chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66257294-66267860
Strand Forward strand
Band q13.2
Transcripts
ENST00000316924 ENSP00000314837
ENST00000394078 ENSP00000377641
ENST00000394067 ENSP00000377631
ENST00000394066 ENSP00000377630
ENST00000394065 ENSP00000377629
ENST00000417856 ENSP00000399403
ENST00000440228 ENSP00000396952
ENST00000421552 ENSP00000408484
ENST00000461611 ENSP00000434538
ENST00000475757 ENSP00000431253
ENST00000483152
ENST00000531240 ENSP00000436577
ENST00000526758 ENSP00000437026
ENST00000534023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0019894 kinesin binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007596 blood coagulation
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0016938 kinesin I complex
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Adaptive Immune System pathway
Immune System pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.280792 Hs.568939 Hs.629588
RefSeq NM_001134774 NM_001134775 NM_001134776 NM_022822 XM_005274182 XM_005274183
HUGO
OMIM
CCDS CCDS44653 CCDS8130
HPRD 13917
IMGT
EMBL
GenPept
RNA Seq Atlas