Version 5.4
Homo sapiens Gene: ANKH
Summary
InnateDB Gene IDBG-13106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKH
Gene Name ankylosis, progressive homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154122
Encoded Proteins
IDBP-13110
ankylosis, progressive homolog (mouse)
IDBP-478705
ankylosis, progressive homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:14704804-14871778
Strand Reverse strand
Band p15.2
Transcripts
ENST00000284268 ENSP00000284268
ENST00000502585
ENST00000503939
ENST00000515517
ENST00000513115
ENST00000503389
ENST00000505140 ENSP00000426332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005315 inorganic phosphate transmembrane transporter activity
GO:0015114 phosphate ion transmembrane transporter activity
GO:0030504 inorganic diphosphate transmembrane transporter activity
Biological Process
GO:0001501 skeletal system development
GO:0007626 locomotory behavior
GO:0030500 regulation of bone mineralization
GO:0030505 inorganic diphosphate transport
GO:0035435 phosphate ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0019867 outer membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022265
View Gene Order
ENSBTAG00000013391
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9HCJ1
TrEMBL B3KMG4 D6RGI5
UniProt Splice Variant
Entrez Gene 56172
UniGene Hs.156727 Hs.702148
RefSeq NM_054027 XM_006714483
HUGO HGNC:15492
OMIM 605145
CCDS CCDS3885
HPRD
IMGT
EMBL AB046801 AC010491 AC016575 AC025456 AF274753 AK001799 AK315012 AY358503 BC009835 BC014526 CH471102
GenPept AAF88039 AAH09835 AAH14526 AAQ88867 BAB13407 BAG37504 BAG50976 EAX08034 EAX08035
RNA Seq Atlas 56172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca