InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wwp1

Summary

InnateDB Gene

IDBG-131115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwp1

Gene Name

WW domain containing E3 ubiquitin protein ligase 1

Synonyms

8030445B08Rik; AIP5; SDRP1; Tiul1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041058

Encoded Proteins

IDBP-131117

WW domain containing E3 ubiquitin protein ligase 1

IDBP-264941

WW domain containing E3 ubiquitin protein ligase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123124:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:19608303-19708993

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035982	ENSMUSP00000041627
ENSMUST00000108246	ENSMUSP00000103881

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0030217	T cell differentiation
GO:0030324	lung development
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated