InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WWP1

Summary

InnateDB Gene

IDBG-27568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWP1

Gene Name

WW domain containing E3 ubiquitin protein ligase 1

Synonyms

AIP5; hSDRP1; Tiul1

Species

Homo sapiens

Ensembl Gene

ENSG00000123124

Encoded Proteins

IDBP-27570

WW domain containing E3 ubiquitin protein ligase 1

IDBP-474955

WW domain containing E3 ubiquitin protein ligase 1

IDBP-479714

WW domain containing E3 ubiquitin protein ligase 1

IDBP-482251

WW domain containing E3 ubiquitin protein ligase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:86342738-86478420

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000265428	ENSP00000265428
ENST00000517970	ENSP00000427793
ENST00000523863
ENST00000518683
ENST00000520374
ENST00000521079
ENST00000520453	ENSP00000429076
ENST00000521997
ENST00000524036
ENST00000520521
ENST00000520798	ENSP00000430228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0016567	protein ubiquitination
GO:0034220	ion transmembrane transport
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046718	viral entry into host cell
GO:0055085	transmembrane transport