Homo sapiens Gene: DYRK4
Summary
InnateDB Gene IDBG-13117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYRK4
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010219
Encoded Proteins
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al., 2005 [PubMed 15607427]).[supplied by OMIM, Mar 2008]
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4562204-4615302
Strand Forward strand
Band p13.32
Transcripts
ENST00000010132 ENSP00000010132
ENST00000539701 ENSP00000441996
ENST00000537719 ENSP00000444842
ENST00000539309 ENSP00000439168
ENST00000538520
ENST00000539490
ENST00000540757 ENSP00000441755
ENST00000536157
ENST00000542905
ENST00000536645
ENST00000543431 ENSP00000439697
ENST00000540644
ENST00000545571
ENST00000536137
ENST00000541024
ENST00000544671 ENSP00000438769
ENST00000544050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439530
RefSeq NM_001282285 NM_001282286 NM_003845
HUGO
OMIM
CCDS CCDS8530
HPRD 10926
IMGT
EMBL
GenPept
RNA Seq Atlas