InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dync2h1

Summary

InnateDB Gene

IDBG-131859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dync2h1

Gene Name

dynein cytoplasmic 2 heavy chain 1

Synonyms

4432416O06Rik; AI448217; b2b414Clo; D030010H02Rik; D330044F14Rik; DHC1b; DHC2; Dnchc2; mKIAA1997

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047193

Encoded Proteins

IDBP-131861

dynein cytoplasmic 2 heavy chain 1

IDBP-542058

dynein cytoplasmic 2 heavy chain 1

IDBP-538579

dynein cytoplasmic 2 heavy chain 1

IDBP-542513

dynein cytoplasmic 2 heavy chain 1

IDBP-538731

dynein cytoplasmic 2 heavy chain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187240:
This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:6928503-7184446

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048417	ENSMUSP00000046733
ENSMUST00000140466	ENSMUSP00000120007
ENSMUST00000147193	ENSMUSP00000116679
ENSMUST00000152934
ENSMUST00000139671	ENSMUSP00000116242
ENSMUST00000147056
ENSMUST00000139115	ENSMUSP00000120322

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007030	Golgi organization
GO:0007368	determination of left/right symmetry
GO:0008105	asymmetric protein localization
GO:0009953	dorsal/ventral pattern formation
GO:0016485	protein processing
GO:0021522	spinal cord motor neuron differentiation
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0035721	intraciliary retrograde transport
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0030286	dynein complex
GO:0031512	motile primary cilium
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome