InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irf5

Summary

InnateDB Gene

IDBG-132026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf5

Gene Name

interferon regulatory factor 5

Synonyms

AW491843; mirf5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029771

Encoded Proteins

IDBP-132028

interferon regulatory factor 5

IDBP-624912

interferon regulatory factor 5

IDBP-624914

interferon regulatory factor 5

IDBP-624917

interferon regulatory factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22412986

Phosphorylation of Irf5 at ser451 and ser462 is the primary trigger of Irf5 function in nuclear accumulation, transcription and apoptosis. (Demonstrated in human)

PMID 25031348

Irf5 modulates West Nile virus pathogenesis and host immune responses by shaping the early pro-inflammatory cytokine response in the draining lymph node.

PMID 25565375

Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.

InnateDB Annotation from Orthologs

Summary

PMID 18332133

[Homo sapiens] IRF5 is activated by both TBK1 and MYD88 to form a homodimer that binds to and activates transcription of type I interferon and inflammatory cytokine genes.

PMID 12600985

[Homo sapiens] IRF5 can act as both an activator and a repressor of interferon (IFN) gene induction dependent on the IRF-interacting partner, and may be a part of the regulatory network that ensures timely expression of the immediate early inflammatory genes.

PMID 22412986

[Homo sapiens] Phosphorylation of IRF5 at ser451 and ser462 is the primary trigger of IRF5 function in nuclear accumulation, transcription and apoptosis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128604:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:29526625-29541869

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000004392	ENSMUSP00000004392
ENSMUST00000164626	ENSMUSP00000130548
ENSMUST00000163511	ENSMUSP00000127021
ENSMUST00000164922
ENSMUST00000167252	ENSMUSP00000126273
ENSMUST00000171527

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	9 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus