Homo sapiens Gene: IRF5 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-40393.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | IRF5 | ||||||||||||||||||||||||||||
Gene Name | interferon regulatory factor 5 | ||||||||||||||||||||||||||||
Synonyms | SLEB10 | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000128604 | ||||||||||||||||||||||||||||
Encoded Proteins |
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
interferon regulatory factor 5
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
IRF5 is activated by both TBK1 and MYD88 to form a homodimer that binds to and activates transcription of type I interferon and inflammatory cytokine genes.
IRF5 can act as both an activator and a repressor of interferon (IFN) gene induction dependent on the IRF-interacting partner, and may be a part of the regulatory network that ensures timely expression of the immediate early inflammatory genes.
Phosphorylation of IRF5 at ser451 and ser462 is the primary trigger of IRF5 function in nuclear accumulation, transcription and apoptosis.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] Phosphorylation of Irf5 at ser451 and ser462 is the primary trigger of Irf5 function in nuclear accumulation, transcription and apoptosis. (Demonstrated in human)
[Mus musculus] Irf5 modulates West Nile virus pathogenesis and host immune responses by shaping the early pro-inflammatory cytokine response in the draining lymph node.
[Mus musculus] Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 7:128937612-128950035 | ||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||
Band | q32.1 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Interferon alpha/beta signaling pathway
Interferon gamma signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | Q13568 | ||||||||||||||||||||||||||||
TrEMBL | A0A024R756 A0A024R763 C9J7M2 C9JAU6 C9JB67 C9JYP7 F8WDH6 I6ZU14 Q64GB0 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 3663 | ||||||||||||||||||||||||||||
UniGene | Hs.614535 | ||||||||||||||||||||||||||||
RefSeq | NM_001098627 NM_001098629 NM_001098630 NM_001242452 NM_032643 XM_005250317 XM_006715974 | ||||||||||||||||||||||||||||
HUGO | HGNC:6120 | ||||||||||||||||||||||||||||
OMIM | 607218 | ||||||||||||||||||||||||||||
CCDS | CCDS43645 CCDS56512 CCDS5808 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AC025594 AY504946 AY504947 AY693665 AY693666 AY693667 AY693668 BC004139 BC004201 CH236950 CH471070 DQ277633 DQ277634 DQ995495 DQ995496 EF064718 JQ950681 U51127 | ||||||||||||||||||||||||||||
GenPept | AAA96056 AAH04139 AAH04201 AAR90325 AAR90326 AAU12877 AAU12878 AAU12879 AAU12880 ABB88960 ABB88961 ABK41901 ABL96293 ABL96294 AFN70752 EAL24107 EAL24108 EAW83703 EAW83704 EAW83705 EAW83706 EAW83707 | ||||||||||||||||||||||||||||
RNA Seq Atlas | 3663 | ||||||||||||||||||||||||||||