InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ciita

Summary

InnateDB Gene

IDBG-132343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ciita

Gene Name

class II transactivator

Synonyms

C2ta; EG669998; Gm9475

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022504

Encoded Proteins

IDBP-132347

class II transactivator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179583:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:10488178-10527564

Strand

Forward strand

Band

Transcripts

ENSMUST00000023147

ENSMUSP00000023147

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	10 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0032403	protein complex binding
GO:0033613	activating transcription factor binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007568	aging
GO:0034341	response to interferon-gamma
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0071257	cellular response to electrical stimulus
GO:0071346	cellular response to interferon-gamma
GO:0071360	cellular response to exogenous dsRNA

Cellular Component

GO:0009986	cell surface
GO:0016605	PML body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000179583

View Gene Order

ENSBTAG00000020649

Not yet available

Pathways

NETPATH

REACTOME

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_230745

Immune System pathway

REACT_198660

Interferon gamma signaling pathway

REACT_198666

Interferon Signaling pathway

KEGG

mmu04612

Antigen processing and presentation pathway

mmu05340

Primary immunodeficiency pathway

mmu05145

Toxoplasmosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25078

Interferon gamma signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa04612

Antigen processing and presentation pathway

hsa05340

Primary immunodeficiency pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

Cross-References

SwissProt

P79621

TrEMBL

Q3U5G4

UniProt Splice Variant

Entrez Gene

12265

UniGene

Mm.249560

RefSeq

NM_001243760 NM_001243761 NM_007575 XM_006521723 XM_006521725

OMIM

CCDS

CCDS27950

HPRD

IMGT

MGI ID

MGI:108445

MGI Symbol

Ciita

EMBL

AF000006 AF000007 AF042158 AF042159 AF100709 AF100710 AK153609 CH466521 U46562 U60653

GenPept

AAB05004 AAB48859 AAB92364 AAB92365 AAC34366 AAC34367 AAF06838 AAF06839 BAE32115 EDK97316

RNA Seq Atlas

12265