Mus musculus Gene: Ciita
Summary
InnateDB Gene IDBG-132343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ciita
Gene Name class II transactivator
Synonyms C2ta; EG669998; Gm9475;
Species Mus musculus
Ensembl Gene ENSMUSG00000022504
Encoded Proteins
class II transactivator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179583:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:10488178-10527564
Strand Forward strand
Band A1
Transcripts
ENSMUST00000023147 ENSMUSP00000023147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 10 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0032403 protein complex binding
GO:0033613 activating transcription factor binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0007568 aging
GO:0034341 response to interferon-gamma
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046677 response to antibiotic
GO:0071257 cellular response to electrical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071360 cellular response to exogenous dsRNA
Cellular Component
GO:0009986 cell surface
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Immune System pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
KEGG
Antigen processing and presentation pathway
Toxoplasmosis pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
KEGG
Antigen processing and presentation pathway
Toxoplasmosis pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P79621
TrEMBL Q3U5G4
UniProt Splice Variant
Entrez Gene 12265
UniGene Mm.249560
RefSeq NM_001243760 NM_001243761 NM_007575 XM_006521723 XM_006521725
OMIM
CCDS CCDS27950
HPRD
IMGT
MGI ID MGI:108445
MGI Symbol Ciita
EMBL AF000006 AF000007 AF042158 AF042159 AF100709 AF100710 AK153609 CH466521 U46562 U60653
GenPept AAB05004 AAB48859 AAB92364 AAB92365 AAC34366 AAC34367 AAF06838 AAF06839 BAE32115 EDK97316
RNA Seq Atlas 12265