InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tpo

Summary

InnateDB Gene

IDBG-132430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpo

Gene Name

thyroid peroxidase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020673

Encoded Proteins

IDBP-132432

thyroid peroxidase

IDBP-624203

thyroid peroxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115705:
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:30054659-30132624

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021005	ENSMUSP00000021005
ENSMUST00000140875
ENSMUST00000155263	ENSMUSP00000133853

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004447	iodide peroxidase activity
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0020037	heme binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0006979	response to oxidative stress
GO:0035162	embryonic hemopoiesis
GO:0042446	hormone biosynthetic process
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process