InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpo

Summary

InnateDB Protein

IDBP-132432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpo

Protein Name

thyroid peroxidase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021005

InnateDB Gene

IDBG-132430 (Tpo)

Protein Structure

UniProt Annotation

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004447	iodide peroxidase activity
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0020037	heme binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0006979	response to oxidative stress
GO:0035162	embryonic hemopoiesis
GO:0042446	hormone biosynthetic process
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:98813

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002007 Haem peroxidase, animal
IPR010255 Haem peroxidase
IPR019791 Haem peroxidase, animal, subgroup

PFAM

PF00084
PF00008
PF07645
PF03098

PRINTS

PR00457

PIRSF

SMART

SM00032
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt