Version 5.4
Mus musculus Gene: Sgk3
Summary
InnateDB Gene IDBG-132609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgk3
Gene Name serum/glucocorticoid regulated kinase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025915
Encoded Proteins
IDBP-132611
serum/glucocorticoid regulated kinase 3
IDBP-626010
serum/glucocorticoid regulated kinase 3
IDBP-626011
serum/glucocorticoid regulated kinase 3
IDBP-626012
serum/glucocorticoid regulated kinase 3
IDBP-790060
serum/glucocorticoid regulated kinase 3
IDBP-790061
serum/glucocorticoid regulated kinase 3
IDBP-790064
serum/glucocorticoid regulated kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104205:
This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011] This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:9798107-9900845
Strand Forward strand
Band A2
Transcripts
ENSMUST00000097826 ENSMUSP00000095437
ENSMUST00000168907 ENSMUSP00000126861
ENSMUST00000166384 ENSMUSP00000130078
ENSMUST00000171265 ENSMUSP00000127462
ENSMUST00000188782 ENSMUSP00000140318
ENSMUST00000188625
ENSMUST00000188738 ENSMUSP00000140496
ENSMUST00000188298 ENSMUSP00000139942
ENSMUST00000188830
ENSMUST00000189050
ENSMUST00000191338
ENSMUST00000188486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006468 protein phosphorylation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005769 early endosome
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104205
View Gene Order
ENSBTAG00000013284
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.336410 Mm.474793
RefSeq NM_001037759 NM_133220 NM_177547
OMIM
CCDS CCDS14816
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca