Version 5.4
Homo sapiens Gene: SGK3
Summary
InnateDB Gene IDBG-23987.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGK3
Gene Name serum/glucocorticoid regulated kinase family, member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104205
Encoded Proteins
IDBP-23991
serum/glucocorticoid regulated kinase family, member 3
IDBP-237164
serum/glucocorticoid regulated kinase family, member 3
IDBP-483291
serum/glucocorticoid regulated kinase family, member 3
IDBP-474645
serum/glucocorticoid regulated kinase family, member 3
IDBP-476418
serum/glucocorticoid regulated kinase family, member 3
IDBP-480205
serum/glucocorticoid regulated kinase family, member 3
IDBP-479260
serum/glucocorticoid regulated kinase family, member 3
IDBP-475959
serum/glucocorticoid regulated kinase family, member 3
IDBP-474531
serum/glucocorticoid regulated kinase family, member 3
IDBP-479981
serum/glucocorticoid regulated kinase family, member 3
IDBP-474309
serum/glucocorticoid regulated kinase family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011] This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:66712418-66862022
Strand Forward strand
Band q13.1
Transcripts
ENST00000345714 ENSP00000331816
ENST00000396596 ENSP00000379842
ENST00000520044
ENST00000519289 ENSP00000429022
ENST00000521198 ENSP00000430463
ENST00000523401
ENST00000494528
ENST00000521960 ENSP00000430475
ENST00000522398 ENSP00000430256
ENST00000522629 ENSP00000429606
ENST00000520976 ENSP00000430691
ENST00000518388 ENSP00000428972
ENST00000519396 ENSP00000428529
ENST00000521152 ENSP00000429565
ENST00000521435
ENST00000523260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015459 potassium channel regulator activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017080 sodium channel regulator activity
GO:0017081 chloride channel regulator activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0030334 regulation of cell migration
GO:0034220 ion transmembrane transport
GO:0042127 regulation of cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0055085 transmembrane transport
Cellular Component
GO:0005769 early endosome
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025915
View Gene Order
ENSBTAG00000013284
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613417 Hs.718900
RefSeq NM_001033578 NM_013257 NM_170709 NM_001204173
HUGO
OMIM
CCDS CCDS6195 CCDS6196
HPRD 06349
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca