InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mmp1a

Summary

InnateDB Gene

IDBG-132664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp1a

Gene Name

matrix metallopeptidase 1a (interstitial collagenase)

Synonyms

Mcol-A; Mcola

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043089

Encoded Proteins

IDBP-132666

matrix metallopeptidase 1a (interstitial collagenase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196611:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:7464141-7476869

Strand

Forward strand

Band

Transcripts

ENSMUST00000034492

ENSMUSP00000034492

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001553	luteinization
GO:0001554	luteolysis
GO:0005976	polysaccharide metabolic process
GO:0006508	proteolysis
GO:0006534	cysteine metabolic process
GO:0009612	response to mechanical stimulus
GO:0010763	positive regulation of fibroblast migration
GO:0010950	positive regulation of endopeptidase activity
GO:0014854	response to inactivity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030574	collagen catabolic process
GO:0033494	ferulate metabolic process
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0071222	cellular response to lipopolysaccharide
GO:0071283	cellular response to iron(III) ion
GO:0071305	cellular response to vitamin D
GO:0071312	cellular response to alkaloid
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071375	cellular response to peptide hormone stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071498	cellular response to fluid shear stress
GO:0071680	response to indole-3-methanol