InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp1a

Summary

InnateDB Protein

IDBP-132666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp1a

Protein Name

matrix metallopeptidase 1a (interstitial collagenase)

Synonyms

Mcol-A; Mcola;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034492

InnateDB Gene

IDBG-132664 (Mmp1a)

Protein Structure

UniProt Annotation

Function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (By similarity). Able to degrade synthetic peptides and type I and II fibrillar collagen. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001553	luteinization
GO:0001554	luteolysis
GO:0005976	polysaccharide metabolic process
GO:0006508	proteolysis
GO:0006534	cysteine metabolic process
GO:0009612	response to mechanical stimulus
GO:0010763	positive regulation of fibroblast migration
GO:0010950	positive regulation of endopeptidase activity
GO:0014854	response to inactivity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030574	collagen catabolic process
GO:0033494	ferulate metabolic process
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0071222	cellular response to lipopolysaccharide
GO:0071283	cellular response to iron(III) ion
GO:0071305	cellular response to vitamin D
GO:0071312	cellular response to alkaloid
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071375	cellular response to peptide hormone stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071498	cellular response to fluid shear stress
GO:0071680	response to indole-3-methanol

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1933846

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References