Mus musculus Gene: Sfrp4
Summary
InnateDB Gene IDBG-132703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sfrp4
Gene Name secreted frizzled-related protein 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021319
Encoded Proteins
secreted frizzled-related protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106483:
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:19623175-19632821
Strand Forward strand
Band A2
Transcripts
ENSMUST00000002883 ENSMUSP00000002883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001944 vasculature development
GO:0002092 positive regulation of receptor internalization
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606 positive regulation of epidermal cell differentiation
GO:0046329 negative regulation of JNK cascade
GO:0046697 decidualization
GO:0055062 phosphate ion homeostasis
GO:0060056 mammary gland involution
GO:0060429 epithelium development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:2000119 negative regulation of sodium-dependent phosphate transport
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Wnt signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Wnt pathway
REACTOME
KEGG
Wnt signaling pathway pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Z1N6
TrEMBL
UniProt Splice Variant
Entrez Gene 20379
UniGene Mm.42095
RefSeq NM_016687
OMIM
CCDS CCDS26261
HPRD
IMGT
MGI ID MGI:892010
MGI Symbol Sfrp4
EMBL AF117709 AF364906 AK080766 BC034853 U88569
GenPept AAD12306 AAH34853 AAL14904 BAC38013
RNA Seq Atlas 20379