Version 5.4
Homo sapiens Gene: SFRP4
Summary
InnateDB Gene IDBG-12815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFRP4
Gene Name secreted frizzled-related protein 4
Synonyms FRP-4; FRPHE; sFRP-4
Species Homo sapiens
Ensembl Gene ENSG00000106483
Encoded Proteins
IDBP-372443
secreted frizzled-related protein 4
IDBP-372446
secreted frizzled-related protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:37905932-38025695
Strand Reverse strand
Band p14.1
Transcripts
ENST00000436072 ENSP00000410715
ENST00000447200 ENSP00000402262
ENST00000478975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001944 vasculature development
GO:0002092 positive regulation of receptor internalization
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0009725 response to hormone
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0022601 menstrual cycle phase
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606 positive regulation of epidermal cell differentiation
GO:0046329 negative regulation of JNK cascade
GO:0046697 decidualization
GO:0055062 phosphate ion homeostasis
GO:0060056 mammary gland involution
GO:0060429 epithelium development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:2000119 negative regulation of sodium-dependent phosphate transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021319
View Gene Order
ENSBTAG00000015366
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.608988 Hs.658169 Hs.710782
RefSeq NM_003014
HUGO
OMIM
CCDS CCDS5453
HPRD 07357
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca