Version 5.4
Mus musculus Gene: Cp
Summary
InnateDB Gene IDBG-132718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cp
Gene Name ceruloplasmin
Synonyms D3Ertd555e
Species Mus musculus
Ensembl Gene ENSMUSG00000003617
Encoded Proteins
IDBP-132720
ceruloplasmin
IDBP-132722
ceruloplasmin
IDBP-264766
ceruloplasmin
IDBP-264768
ceruloplasmin
IDBP-264772
ceruloplasmin
IDBP-627629
ceruloplasmin
IDBP-627630
ceruloplasmin
IDBP-627631
ceruloplasmin
IDBP-627632
ceruloplasmin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:19957054-20009145
Strand Forward strand
Band A2
Transcripts
ENSMUST00000091309 ENSMUSP00000088857
ENSMUST00000003714 ENSMUSP00000003714
ENSMUST00000108329 ENSMUSP00000103965
ENSMUST00000108328 ENSMUSP00000103964
ENSMUST00000108325 ENSMUSP00000103961
ENSMUST00000128615
ENSMUST00000131454
ENSMUST00000150264
ENSMUST00000125994
ENSMUST00000131811
ENSMUST00000129135
ENSMUST00000174803
ENSMUST00000172605 ENSMUSP00000134347
ENSMUST00000173848 ENSMUSP00000133676
ENSMUST00000172860 ENSMUSP00000133374
ENSMUST00000173779 ENSMUSP00000133643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004322 ferroxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0051087 chaperone binding
Biological Process
GO:0006825 copper ion transport
GO:0006879 cellular iron ion homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000047457
View Gene Order
ENSBTAG00000012164
Not yet available
Pathways
NETPATH
REACTOME
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_205755
Iron uptake and transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_251299
Metal ion SLC transporters pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL G3X9T8 Q2F3J4 Q8BV37
UniProt Splice Variant
Entrez Gene 12870
UniGene Mm.13787 Mm.438250 Mm.447443
RefSeq NM_001042611 NM_001276248 NM_001276250 NM_007752 XM_006535381
OMIM
CCDS CCDS38401 CCDS71227
HPRD
IMGT
MGI ID MGI:88476
MGI Symbol Cp
EMBL AC079442 AK080701 CH466530 DQ336396
GenPept ABC68391 BAC37984 EDL34888
RNA Seq Atlas 12870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca