InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cp

Summary

InnateDB Protein

IDBP-132720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

ceruloplasmin

Synonyms

D3Ertd555e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088857

InnateDB Gene

IDBG-132718 (Cp)

Protein Structure

UniProt Annotation

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in many tissues, including liver, eye and brain. {ECO:0000269PubMed:8690795}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0051087	chaperone binding

Biological Process

GO:0006825	copper ion transport
GO:0006879	cellular iron ion homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:88476

InterPro

IPR008972 Cupredoxin
IPR011706 Multicopper oxidase, type 2
IPR011707 Multicopper oxidase, type 3

PFAM

PF07731
PF07732

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61147

PhosphoSite

PhosphoSite-Q61147

TrEMBL

Q8BV37

UniProt Splice Variant

Entrez Gene

12870

UniGene

Mm.447443

RefSeq

NP_031778

MGI ID

MGI Symbol

OMIM

CCDS

CCDS38401

HPRD

IMGT

EMBL

AK080701 BC062957 DQ336396 U49430

GenPept

AAB07996 AAH62957 ABC68391 BAC37984