InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dld

Summary

InnateDB Gene

IDBG-132997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dld

Gene Name

dihydrolipoamide dehydrogenase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020664

Encoded Proteins

IDBP-259355

dihydrolipoamide dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:31331564-31351437

Strand

Reverse strand

Band

Transcripts

ENSMUST00000110857

ENSMUSP00000106481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004148	dihydrolipoyl dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006508	proteolysis
GO:0007369	gastrulation
GO:0008033	tRNA processing
GO:0042391	regulation of membrane potential
GO:0045454	cell redox homeostasis
GO:0048240	sperm capacitation
GO:0055114	oxidation-reduction process