Mus musculus Gene: Dld
Summary
InnateDB Gene IDBG-132997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dld
Gene Name dihydrolipoamide dehydrogenase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020664
Encoded Proteins
dihydrolipoamide dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:31331564-31351437
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000110857 ENSMUSP00000106481
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006508 proteolysis
GO:0007369 gastrulation
GO:0008033 tRNA processing
GO:0042391 regulation of membrane potential
GO:0045454 cell redox homeostasis
GO:0048240 sperm capacitation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005929 cilium
GO:0043159 acrosomal matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The citric acid (TCA) cycle and respiratory electron transport pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Pyruvate metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Lysine catabolism pathway
Citric acid cycle (TCA cycle) pathway
Branched-chain amino acid catabolism pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Citrate cycle (TCA cycle) pathway
Glycine, serine and threonine metabolism pathway
Valine, leucine and isoleucine degradation pathway
Pyruvate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Branched-chain amino acid catabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
Pyruvate metabolism pathway
Metabolism of amino acids and derivatives pathway
Lysine catabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Citrate cycle (TCA cycle) pathway
Glycine, serine and threonine metabolism pathway
Valine, leucine and isoleucine degradation pathway
Pyruvate metabolism pathway
INOH
Glycine Serine metabolism pathway
Citrate cycle pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O08749
TrEMBL
UniProt Splice Variant
Entrez Gene 13382
UniGene Mm.3131 Mm.471230
RefSeq NM_007861
OMIM
CCDS CCDS36428
HPRD
IMGT
MGI ID MGI:107450
MGI Symbol Dld
EMBL AK117104 AK136193 AK153399 AK168875 BC003368 U73445
GenPept AAC53170 AAH03368 BAE22867 BAE31961 BAE40693 BAE43405
RNA Seq Atlas 13382