InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105088

Summary

InnateDB Gene

IDBG-632271.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105088

Gene Name

dihydrolipoyl dehydrogenase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001908

Encoded Proteins

IDBP-683991

Dihydrolipoyl dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091140:
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. [provided by RefSeq, Jul 2008]
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:49230967-49257713

Strand

Forward strand

Band

Transcripts

ENSBTAT00000033787

ENSBTAP00000033696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004148	dihydrolipoyl dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006508	proteolysis
GO:0007369	gastrulation
GO:0008033	tRNA processing
GO:0042391	regulation of membrane potential
GO:0045454	cell redox homeostasis
GO:0048240	sperm capacitation
GO:0055114	oxidation-reduction process