Version 5.4
Homo sapiens Gene: KCNA5
Summary
InnateDB Gene IDBG-13330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNA5
Gene Name potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1
Species Homo sapiens
Ensembl Gene ENSG00000130037
Encoded Proteins
IDBP-13332
potassium voltage-gated channel, shaker-related subfamily, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:5043989-5046788
Strand Forward strand
Band p13.32
Transcripts
ENST00000252321 ENSP00000252321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
GO:0019870 potassium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0051393 alpha-actinin binding
GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0097110 scaffold protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0019229 regulation of vasoconstriction
GO:0042391 regulation of membrane potential
GO:0043266 regulation of potassium ion transport
GO:0043267 negative regulation of potassium ion transport
GO:0050796 regulation of insulin secretion
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0071435 potassium ion export
GO:0086014 atrial cardiac muscle cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000288 positive regulation of myoblast proliferation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0008076 voltage-gated potassium channel complex
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0030018 Z disc
GO:0045121 membrane raft
GO:0046691 intracellular canaliculus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045534
View Gene Order
ENSBTAG00000007553
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P22460
TrEMBL
UniProt Splice Variant
Entrez Gene 3741
UniGene Hs.150208
RefSeq NM_002234
HUGO HGNC:6224
OMIM 176267
CCDS CCDS8536
HPRD
IMGT
EMBL BC096357 BC096358 BC099665 BC099666 M55513 M60451 M83254
GenPept AAA36422 AAA60146 AAA61276 AAH96357 AAH96358 AAH99665 AAH99666
RNA Seq Atlas 3741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca