InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNA5

Summary

InnateDB Protein

IDBP-13332.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA5

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 5

Synonyms

ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000252321

InnateDB Gene

IDBG-13330 (KCNA5)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. {ECO:0000269PubMed:11524461, ECO:0000269PubMed:8505626}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269PubMed:16772329}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Pancreatic islets and insulinoma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity
GO:0019870	potassium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0051393	alpha-actinin binding
GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0097110	scaffold protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0019229	regulation of vasoconstriction
GO:0042391	regulation of membrane potential
GO:0043266	regulation of potassium ion transport
GO:0043267	negative regulation of potassium ion transport
GO:0050796	regulation of insulin secretion
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055075	potassium ion homeostasis
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0071435	potassium ion export
GO:0086014	atrial cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000288	positive regulation of myoblast proliferation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008076	voltage-gated potassium channel complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030018	Z disc
GO:0045121	membrane raft
GO:0046691	intracellular canaliculus
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003972 Potassium channel, voltage dependent, Kv1
IPR004052 Potassium channel, voltage dependent, Kv1.5
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF02214
PF00520
PF07885
PF08016

PRINTS

PR00169
PR01491
PR01496
PR01512

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt