InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm1

Summary

InnateDB Gene

IDBG-133363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm1

Gene Name

glutamate receptor, metabotropic 1

Synonyms

4930455H15Rik; ENSMUSG00000075319; Gm10828; Gprc1a; mGluR1; nmf373; rcw; wobl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019828

Encoded Proteins

IDBP-133365

glutamate receptor, metabotropic 1

IDBP-270608

glutamate receptor, metabotropic 1

IDBP-270610

glutamate receptor, metabotropic 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152822:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq, Jul 2008]
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:10686059-11082356

Strand

Reverse strand

Band

Transcripts

ENSMUST00000044306	ENSMUSP00000037255
ENSMUST00000105561	ENSMUSP00000101190
ENSMUST00000105560	ENSMUSP00000101189
ENSMUST00000155772
ENSMUST00000135120
ENSMUST00000156826

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001639	PLC activating G-protein coupled glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0038042	dimeric G-protein coupled receptor signaling pathway
GO:0043408	regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051930	regulation of sensory perception of pain
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0038037	G-protein coupled receptor dimeric complex
GO:0038038	G-protein coupled receptor homodimeric complex
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane