Homo sapiens Gene: GRM1
Summary
InnateDB Gene IDBG-97580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRM1
Gene Name glutamate receptor, metabotropic 1
Synonyms GPRC1A; MGLU1; MGLUR1; PPP1R85; SCAR13;
Species Homo sapiens
Ensembl Gene ENSG00000152822
Encoded Proteins
glutamate receptor, metabotropic 1
glutamate receptor, metabotropic 1
glutamate receptor, metabotropic 1
glutamate receptor, metabotropic 1
glutamate receptor, metabotropic 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq, Jul 2008]
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:146027646-146437598
Strand Forward strand
Band q24.3
Transcripts
ENST00000355289 ENSP00000347437
ENST00000282753 ENSP00000282753
ENST00000361719 ENSP00000354896
ENST00000507005
ENST00000502405
ENST00000492807 ENSP00000424095
ENST00000507907 ENSP00000425599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008219 cell death
GO:0019233 sensory perception of pain
GO:0038042 dimeric G-protein coupled receptor signaling pathway
GO:0043408 regulation of MAPK cascade
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051930 regulation of sensory perception of pain
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0071257 cellular response to electrical stimulus
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0038037 G-protein coupled receptor dimeric complex
GO:0038038 G-protein coupled receptor homodimeric complex
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
INOH
GPCR signaling pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
PID NCI
Cross-References
SwissProt Q13255
TrEMBL
UniProt Splice Variant
Entrez Gene 2911
UniGene Hs.32945
RefSeq NM_001278067 NM_001278066 NM_001278065 NM_001278064 XM_006715467
HUGO HGNC:4593
OMIM 604473
CCDS CCDS64548 CCDS47497 CCDS5209
HPRD 05129
IMGT
EMBL AL031769 AL035698 AL096867 AL592423 BC136280 BC143779 L76627 L76631 U31215 U31216
GenPept AAA87843 AAA87844 AAB05337 AAB05338 AAI36281 CAH71181 CAH71182 CAI20335 CAI20336 CAI22468 CAI22469
RNA Seq Atlas 2911