Mus musculus Gene: Slc26a4
Summary
InnateDB Gene IDBG-133378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc26a4
Gene Name solute carrier family 26, member 4
Synonyms Pds; pendrin;
Species Mus musculus
Ensembl Gene ENSMUSG00000020651
Encoded Proteins
solute carrier family 26, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091137:
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3\' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:31519827-31559969
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000001253 ENSMUSP00000001253
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
Biological Process
GO:0006821 chloride transport
GO:0006885 regulation of pH
GO:0008272 sulfate transport
GO:0009887 organ morphogenesis
GO:0015698 inorganic anion transport
GO:0015705 iodide transport
GO:0032880 regulation of protein localization
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Multifunctional anion exchangers pathway
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Multifunctional anion exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9R155
TrEMBL
UniProt Splice Variant
Entrez Gene 23985
UniGene Mm.100187
RefSeq NM_011867 XM_006515091 XM_006515092
OMIM
CCDS CCDS36429
HPRD
IMGT
MGI ID MGI:1346029
MGI Symbol Slc26a4
EMBL AF167411
GenPept AAD51617
RNA Seq Atlas 23985